Evaluation of Versant Hepatitis C Virus Genotype Assay (LiPA) 2.0
نویسندگان
چکیده
منابع مشابه
Evaluation of Versant hepatitis C virus genotype assay (LiPA) 2.0.
Hepatitis C virus (HCV) genotyping is a tool used to optimize antiviral treatment regimens. The newly developed Versant HCV genotype assay (LiPA) 2.0 uses sequence information from both the 5' untranslated region and the core region, allowing distinction between HCV genotype 1 and subtypes c to l of genotype 6 and between subtypes a and b of genotype 1. HCV-positive samples were genotyped manua...
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Hepatitis C virus (HCV) is a major cause of chronic liver disease, the prevalence of the infection being currently estimated at approximately 170 milion persons worldwide. HCV isolates have been classified into six main genotypes. Quick and accurate genotyping of HCV is becoming increasingly important for clinical management of chronic infection and as an epidemiological marker. Genotyping meth...
متن کاملSequencing assays for failed genotyping with the versant hepatitis C virus genotype assay (LiPA), version 2.0.
For optimal antiviral therapy, the hepatitis C virus (HCV) genotype needs to be determined, as it remains a strong predictor of sustained viral response. In this study, we assessed the number of HCV genotyping results that could not be determined using the commercially available line probe assay (LiPA) (Versant hepatitis C virus genotype 2.0 assay) in a large international panel of samples from...
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Introduction The VERSANT HCV Genotype 2.0 Assay (LiPA) is a line probe assay for the identification of HCV genotypes and differentiation of HCV subtypes in HCV RNA positive human serum or EDTA plasma specimens. The assay is intended to be used to guide the selection of treatment type and duration for individuals being considered for antiviral treatment and who are chronically infected with HCV....
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Hepatitis C virus (HCV) isolates have been classified into six main genotypes. Genotyping methods, and especially the widely used line probe assay (LiPA), are frequently based on the 5'-untranslated region (5'UTR). However, this region is not appropriate for discriminating HCV strains at the subtype level and for distinguishing many genotype 6 samples from genotype 1. We investigated the capaci...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2008
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.02390-07